An in silico high-throughput screen identifies potential selective inhibitors for the non-receptor tyrosine kinase Pyk2

Tomer Meirson, Abraham O Samson, Hava Gil-Henn Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel Abstract: The non-receptor tyrosine kinase proline-rich tyrosine kinase 2 (Pyk2) is a critical mediator of signaling from cell surface growth factor and adhesion receptors to cell migration, proliferation, and survival.Emerging evid

read more


The Impact of Behavioral and Structural Remedies on Electricity Prices: The Case of the England and Wales Electricity Market

During the liberalization process the UK regulatory authority introduced a behavioral remedy (through price-cap regulation) and structural remedy (through divestment series) in order to mitigate an exercise of market power and lower the influence of incumbent producers on wholesale Hat Racks electricity prices.We study the impact of these remedies

read more

Gut microbiota dynamics and functionality in Reticulitermes grassei after a 7-day dietary shift and ciprofloxacin treatment.

Gut microbial structure in animals depends on the host, dietary habits and local environment.A random event, dietary change or antibiotic treatment may alter the gut environment with possible repercussions for the bacterial community composition and functionality and ultimately host fitness.The present study was focused on the composition, structur

read more

A Tri-O-Bridged Diels-Alder Adduct from Cortex Mori Radicis

Sanggenon X, an unusual tri-O-bridged Diels-Alder adduct, was isolated from Cortex Mori Radicis.Its structure was established by spectroscopic analysis, including Facial Moisturizers NMR and HR-MS (High Resolution Mass Spectrometry).Sanggenon X contained three O-bridged rings, where the oxygenated bridgeheads were all quaternary carbons.Chemical me

read more